Paroxysmal hypnogenic dyskinesia is a rare clinical entity characterized by intermittent dystonia and choreoathetoid movements that begin exclusively during sleep, often with consciousness preserved once the patient is awakened during the episodes.They occur almost every Molasses Catcher night and are often misdiagnosed as sleeping disorders.Paroxy
Growth associated protein 43 is expressed in skeletal muscle fibers and is localized in proximity of mitochondria and calcium release units.
The neuronal Growth Associated Protein 43 (GAP43), also known as B-50 or neuromodulin, is involved in mechanisms controlling pathfinding and branching of Bicycle Trailers neurons during development and regeneration.For many years this protein was classified as neuron-specific, but recent evidences suggest that a) GAP43 is expressed in the nervous s
The Use of SMAV Model for Computing Fragility Curves
Among the buildings with strategic role for civil protection purposes part of them were built before the introduction of modern seismic codes.Aiming to guarantee their operability in case of seismic events, they have to be assessed and, hopefully, seismically upgraded.This aspect arises the necessity of reliable low computational demanding numerica
Cycling and walking to work in New Zealand, 1991-2006: regional and individual differences, and pointers to effective interventions
Abstract Background Active commuting increases levels of physical activity and is more likely to be adopted and sustained than exercise programmes.Despite the potential health, environmental, social and economic benefits, cycling and walking are increasingly marginal modes of transport in many countries.This paper investigated regional and individu
In Vivo Targeting of Clostridioides difficile Using Phage-Delivered CRISPR-Cas3 Antimicrobials
ABSTRACT Clostridioides difficile is an important nosocomial pathogen that causes approximately 500,000 cases of C.difficile infection (CDI) and 29,000 deaths annually in the United States.Antibiotic use is a major risk factor for CDI because broad-spectrum antimicrobials disrupt the indigenous gut microbiota, decreasing colonization resistance aga